LYMPHOID NEOPLASIA Evidence for the significant role of immunoglobulin light chains in antigen recognition and selection in chronic lymphocytic leukemia
نویسندگان
چکیده
1Institute of Agrobiotechnology, Centre for Research and Technology, Thessaloniki, Greece; 2Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece; 3Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; 4Hematology Department, Nikea General Hospital, Athens, Greece; 5HLA Tissue Typing, Immunohematology and Transfusion Medicine Service, Istituto Scientifico San Raffaele, Milan, Italy; 6Laborary of Hematology and Université Pierre et Marie Curie, Hôpital Pitié-Salpètrière, Paris, France; and 7Laboratory and Unit of Lymphoid Malignancies, Department of Oncology, Università Vita-Salute, San Raffaele and Istituto Scientifico San Raffaele, Milan, Italy
منابع مشابه
Evidence for the significant role of immunoglobulin light chains in antigen recognition and selection in chronic lymphocytic leukemia.
We analyzed somatic hypermutation (SHM) patterns and secondary rearrangements involving the immunoglobulin (IG) light chain (LC) gene loci in 725 patients with chronic lymphocytic leukemia (CLL). Important differences regarding mutational load and targeting were identified in groups of sequences defined by IGKV/IGLV gene usage and/or K/LCDR3 features. Recurrent amino acid (AA) changes in the IG...
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Somatic mutations of immunoglobulin genes characterize mature memory B cells, and intraclonal B-cell diversification is typically associated with expansion of B-cell clones with greater affinity for antigen (antigen drive). Evidence for a role of antigen in progression of intraclonal chronic lymphocytic leukemia (CLL) cell diversification in patients with mutated immunoglobulin genes has not be...
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Chronic lymphocytic leukemia (CLL) is a malignancy of B CD5+cells and is the most common type of leukemia in adults. The disease is more common in men over 50 years in western countries. CLL is associated with defective apoptosis in B cells. CLL was traditionally regarded as a disease that occurs before naïve B cells meet the antigen in the lymph nodes. Laboratory diagnosis requires white blood...
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متن کاملSubsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia.
We recently identified a chronic lymphocytic leukemia (CLL) subgroup using the immunoglobulin variable heavy-chain (V(H)) gene V(H)3-21 with almost identical heavy-chain complementarity determining region 3s (HCDR3s) and preferential variable light-chain (V(L)) gene usage, suggesting recognition of a common antigen epitope in this subset. To further explore the B-cell receptors (BCRs) in CLL, w...
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